Le tableau ci-dessous reprend la liste des 30 « Rapid Alerts » européennes où la limite légale belge de 6 femmes, ayant eu au moins un enfant par donneur, a été dépassée (à partir de 2022). Nombre de femmes ayant eu au moins un enfant (traitement en Belgique).
Les données présentées dans ce tableau dépendent des informations communiquées par les centres de fertilité. Ces données sont susceptibles d'évoluer. L’agence ne peut garantir leur exhaustivité ni leur exactitude. Le nombre de grossesses repris dans ce tableau ne correspond pas nécessairement à des grossesses avérées ni à des naissances. Il peut exister une différence entre le nombre de grossesses, le nombre d’enfants et les données disponibles au moment de la déclaration (p. ex. grossesses interrompues, grossesses encore en cours, nouvelles grossesses).
Il est important de noter que le blocage d’un donneur n’empêche pas l’utilisation de ses gamètes pour un projet parental concernant des frères et sœurs déjà nés de don de ce donneur. Ainsi, même si le nombre de familles n’augmentera plus, le nombre d’enfants au sein d’une même famille peut encore évoluer.
Une Rapid Alert est une notification émise par une autorité compétente d’un Etat membre de l’Union européenne afin d’informer les autres Etats membres impliqués en cas de risque sanitaire lié à l'utilisation de tissus et cellules. Lorsqu’un donneur de sperme fait l’objet d’une Rapid Alert, il est bloqué de manière permanente et son sperme ne peut plus être utilisé pour le traitement d'une nouvelle femme.
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Banque de sperme du donneur |
Autres pays utilisateurs du donneur |
Nombre de femmes ayant eu au moins un enfant en Belgique |
Nombre d'enfants |
Nombre de centres belges de fertilité qui ont reçu le sperme du donneur |
Année d'émission de la Rapid Alert |
Risque confirmé à l'utilisation du sperme du donneur |
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Donor 1 |
ESB |
AT, DE, FI, FR, IE, IS, MT, NL, NO, PT, SE, XI |
7 |
9 |
6 |
2022 |
First blockage: Donor is a carrier of classic galactosemia. His gametes are permanently blocked 23MAY2022. Second blockage: The donor is carrier of Shwachman-Diamond syndrome. His gametes were already permanently blocked in May 2022 due to his carrier status of classic galactosemia. |
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Donor 2 |
ESB |
BG, ES, GR, HU, IT, LV, PL |
20 |
20 |
13 |
2022 |
A pathogenic variant in the PHA gene has been identified in donor and he is a carrier of PKU why his gametes are permanently blocked 11JUL2022. |
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Donor 3 |
ESB |
AT, CY, DE, FI, HU, IE, IS, MT, NL, NO, PT, SE, XI |
10 |
10 |
5 |
2022 |
Donor is a carrier of autosomal recessive inherited mild-to-moderate sensorineural hearing loss due to a STRC deletion and according to the current interpretation of the Danish legislation his gametes are permanently blocked 02SEP2022. |
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Donor 4 |
ESB |
AT CY DE FI IE IS NL NO PT SE XI |
14 |
14 |
4 |
2022 |
The donor is a carrier of congenital disorder of glycosylation type Ia. His gametes are permanently blocked 15DEC2022. |
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Donor 5 |
ESB |
HU PL |
17 |
22 |
13 |
2023 |
Hip dysplasia in a donor confers an increased risk to his offspring. His gametes are permanently blocked 18JAN2023. |
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Donor 6 |
ESB |
GR IE PL |
9 |
11 |
8 |
2023 |
Donor is a carrier of c.10955delC(p.Pro3652Glnfs*2) in the PKHD1 gene. His gametes are to be permanently blocked 20MAR2023. |
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Donor 7 |
ESB |
PL |
11 |
11 |
9 |
2023 |
A deletion of exon 11-14 in the GLI2 gene in a donor child does confer an increased risk to donor’s offspring. His gametes are permanently blocked 24MAR2023. |
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Donor 8 |
ESB |
ES GR HU |
8 |
10 |
8 |
2023 |
Donor is compound heterozygous for hemochromatosis. His gametes are therefore permanently blocked 15JUN2023. |
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Donor 9 |
ESB |
ES GR IE IS IT LV PL |
8 |
8 |
7 |
2023 |
A duplication of 22q11 in the donor might confer an increased risk to his offspring. His gametes are permanently blocked 04JUL2023. |
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Donor 10 |
ESB |
AT DE FI FR GB IE IS NL NO PT SE |
12 |
16 |
5 |
2023 |
The genetic examination of the donor shows that he has a deletion in exon 16-29 of the STRC gene. Hearing impairment in a donor child may confer an increased risk to donor’s offspring. Donor’s gametes are blocked 05JUL2023. |
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Donor 11 |
ESB |
AT CY DE EE FI FR GB IE IS NL NO PT SE |
10 |
11 |
4 |
2023 |
Donor investigation shows donor to be a carrier of 57kb deletion in the CTNS-gene. A 57 kb deletion in CTNS-gene in a donor child does confer an increased risk to donor’s offspring. Donor’s gametes are to be permanently blocked 08AUG2023. |
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Donor 12 |
ESB |
BG CY DE ES GR HU IE IS NL PL |
38 |
53 |
14 |
2023 |
TP53 variant in a donor does confer an increased risk to donor’s offspring. His gametes are permanently blocked 30OCT2023. |
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Donor 13 |
ESB |
ES IT LV |
12 |
15 |
8 |
2023 |
The donor has been under investigation and the results have shown that he is a carrier of neonatal Zellweger syndrome, since he is heterozygous for the mutation in the PEX6 gene. Zellweger syndrome in a donor child does confer an increased risk to donor’s offspring. His gametes are permanently blocked 07DEC2023. |
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Donor 14 |
ESB |
AT DE FI IE IS LU MT NL NO PT SE XI |
11 |
12 |
6 |
2023 |
Genetic testing showed that Donor is carrier of one of the two RAG2 variants. RAG2 deficiency results in the severe phenotype Severe combined immune deficiency SCID. Due to the fact that donor is known carrier of a recessive gene variant he is permanently blocked 08NOV2023. |
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Donor 15 |
ESB |
AT DE GB IS NL NO PT SE |
7 |
8 |
4 |
2024 |
Isovaleric acidemia in a donor child, and subsequent genetic analysis showing that donor is heterozygous carrier of a pathogenic variant in the IVD gene; c.158G>A, p.Arg53His, does confer an increased risk to donor’s offspring. His gametes are therefore permanently blocked 20DEC2023. |
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Donor 16 |
ESB |
HU |
10 |
10 |
10 |
2024 |
The donors Family history reveals that the PD has an unspecified hernia, his identical twin brother was born with coarctation of his aorta and his paternal aunt was born with only one kidney. Hydronephrosis in a donor child does confer an increased risk to donor’s offspring. His gametes are therefore permanently blocked 31Jan2024. |
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Donor 17 |
ESB |
BG EE ES GR HU IE IT LV PL |
18 |
23 |
9 |
2024 |
MSH2 variant in a donor does confer an increased risk to donor’s offspring. His gametes are to be permanently blocked. |
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Donor 18 |
ESB |
ES GR |
14 |
16 |
8 |
2024 |
The pathogenic variant ing the GAA gene was identified in the donor. Biallellic pathogenic variants in the GAA gene cause Pompes disease. A pathogenic variant in the GAA gene does confer an increased risk to a donor child. His gametes are to be permanently blocked. |
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Donor 19 |
ESB |
ES IT MT PL |
8 |
12 |
9 |
2024 |
Pathogenic MYBPC3 variant in a fetus and found in the donor confers an increased risk to donor’s offspring. His gametes are permanently blocked 07NOV2024. |
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Donor 20 |
ESB |
BG CY ES GR HU IS IT LV PL RO |
21 |
24 |
10 |
2024 |
Cardiomyopathy in a donor child and subsequent diagnosis of heterozygosity of a pathogenic variant in APLK3 gene in the donor confers an increased risk to donor’s offspring. The donor is blocked and his gametes can no longer be used. The case is closed and reported to the Danish Patient Safety Authorities. 19NOV2024. |
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Donor 21 |
ESB |
BG EE FR GR HU IS LT LV PL RO |
17 |
20 |
10 |
2025 |
Investigation of donor shows a 109kb deletion involving the NRXN1 gene. Donor will be permanently blocked 21JAN2025. |
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Donor 22 |
Cryos |
AT BG CY DE ES FR GB GR HU IE IT LU LV NL PL RO SE |
11 |
12 |
4* |
2025 |
Donor has been tested and carries a variant in USH2A. The risk of an affected child is lower than 1%. Donor gametes were blocked for new customers (<1% recurrence risk) 02NOV2022 but can be used for siblings. Reported to the Danish Patient Safety Authority 25FEB2025. |
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Donor 23 |
ESB |
BG CY EE ES GR HU IT LV PL |
27 |
34 |
14 |
2025 |
The donor has been investigated and has an extraordinary genetic constellation since he has 3 copies of the FBN1 gene: 2 normal FBN1 genes and a copy of FBN1 with deletion of exon 1-4. Donor gametes are blocked 30APR 2025. We recommend that donor conceived children of donor are referred for paediatric evaluation to assess the relevance of genetic counselling and examination. |
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Donor 24 |
ESB |
AT CY DE FR GB GR IE IS NL PT SE |
10 |
10 |
5 |
2025 |
We can conclude that the donor has a genotype with a deletion of SMN1 on one chromosome and two copies of SMN1 on the other chromosome. The donor will be permanently blocked 20JAN2025. |
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Donor 25 |
ESB |
BG CY CZ EE ES GR HU IE IS IT LT LU PL RO |
19 |
27 |
12 |
2025/2026 |
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Donor 26 |
ESB |
FR GR HU IS LV PL |
9 |
9 |
8 |
2025 |
Deletion of the CYP21A2 gene in a donor does confer an increased risk to donor’s offspring. His gametes are to be permanently blocked. The case is closed and reported to the Danish Patient Safety Authorities. 19AUG2025. |
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Donor 27 |
ESB |
ES IT NL PL |
12 |
15 |
10* |
2025 |
A pathogenic (class V) genetic variant was observed in the Thyroglobulin (TG) gene. Congenital hypothyroidism in a donor child does confer an increased risk to donor’s offspring. His gametes are to be permanently blocked. The case is closed and is to be reported to the Danish Patient Safety Authorities. 13OCT2025. |
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Donor 28 |
ESB |
BG CY DE ES FR GR HU IE IS IT LT LU LV PL RO SE XI |
22 |
29 |
10 |
2025 |
The donor is a carrier of Metachromatic leukodystrophy (MLD), since a pathogenic genetic variant in the Arylsulfatase A (ARSA) gene is identified in a heterozygous state. A pathogenic genetic variant :NM_000487.6:c.917C>T, identified in the donor does confer an increased reproductive risk. His gametes are to be permanently blocked. 20OCT2025. |
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Donor 29 |
ESB |
BG CY EE ES FR GR HU IE IS IT LV PL |
14 |
22 |
10 |
2025 |
The donor has been under investigation and the results have shown that he is a healthy carrier of Spinal Muscular Atrophy, since MLPA analysis shows a deletion of one of the SMN1 genes. |
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Donor 30 |
ESB |
BG CY EE FR GR HU IS LV PL RO |
10 |
11 |
10 |
2025 |
The CHEK2 variant c1100delC found in the donor confers an increased risk to donor's offspring. The donor will be permanently blocked and the case reported to Danish health authorities. 27NOV2025 |
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* private recipient(s)